Responses and pharmacological properties of preoptic/anterior hypothalamic neurones following medial forebrain bundle stimulation.
نویسندگان
چکیده
منابع مشابه
Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences.
Extracellular dopamine levels were measured in the rat nucleus accumbens by means of in vivo microdialysis. Delivery of rewarding medial forebrain bundle stimulation at a low rate (5 trains/min) produced a sustained elevation of dopamine levels, regardless of whether train onset was predictable. When the rate of train delivery was increased to 40 trains/min, dopamine levels rose rapidly during ...
متن کاملRegional differences in desensitization of c-Fos expression following repeated self-stimulation of the medial forebrain bundle in the rat.
The acute self-stimulation of the medial forebrain bundle was reported to induce the expression of c-Fos, the protein product of c-fos, an immediate early gene, in the central nervous system. In the present study, we examined regional changes in c-Fos expression in several reward-related areas of rat brain in response to short- and long-term exposure to self-stimulation of the medial forebrain ...
متن کاملTemporary inactivation of the retrorubral fields decreases the rewarding effect of medial forebrain bundle stimulation.
Prior studies indicate that lesioning the retrorubral fields (RRF) decreases the rewarding effect of medial forebrain bundle (MFB) stimulation, although these studies did not make the RRF their primary target. This study directly investigates the role of the RRF in MFB self-stimulation using transient lidocaine-induced inactivation of target tissue rather than permanent lesioning. In 18 rats wi...
متن کاملTransient release of dopamine in response to rewarding stimulation of the medial forebrain bundle
Entitled: Transient release of dopamine in response to rewarding stimulation of the medial forebrain bundle and submitted in partial fulfillment of the requirements for the degree of Master of Arts (Psychology) complies with the regulations of the University and meets the accepted standards with respect to originality and quality. _________20___ ______Brian Lewis___________________________ Dean...
متن کاملEvidence implicating descending fibers in self-stimulation of the medial forebrain bundle.
The role of ascending and descending fibers in self-stimulation of the lateral hypothalamus and ventral tegmental area in the rat was assessed by noting whether anodal hyperpolarization of one of these sites could reduce the rewarding effect of stimulating the other site. Strength-duration curves were obtained by psychophysical means, with one of the depth electrodes serving as the cathode and ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1978
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1978.sp012348